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Case Reports
. 2015 Jul 1;7(1):e2015043.
doi: 10.4084/MJHID.2015.043. eCollection 2015.

Leukocyte Derived Chemotaxin 2 (ALECT2) Amyloidosis

Uday Kulkarni  1 , Anna Valson  2 , Anila Korula  3 , Vikram Mathews  1
Affiliations
Case Reports

Leukocyte Derived Chemotaxin 2 (ALECT2) Amyloidosis

Uday Kulkarni et al. Mediterr J Hematol Infect Dis. .

Abstract

We describe the first case from India of ALECT2 amyloidosis. An adult Punjabi male presented with progressive renal dysfunction and non-nephrotic range proteinuria. Serum protein electrophoresis and immunofixation were normal, with mildly elevated serum free light chain ratio. A renal biopsy confirmed the presence of amyloid. Immunohistochemistry was negative for monoclonal light chains. Proteomic analysis confirmed the presence of ALECT2 amyloid. The present case highlights the need for confirmatory testing for typing of amyloid.

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Figures

Figure 1
Figure 1
Glomerular, mesangial, capillary and interstitial amyloid deposits (hematoxylin and eosin staining × 200)
See this image and copyright information in PMC

References

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