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. 2015 Jun;3(6):508-9.
doi: 10.1002/ccr3.275. Epub 2015 Apr 9.

Topiramate-induced nephrolithiasis

Eleni Z Giannopoulou  1 , Ludwig Gortner  1 , Sylvia Peterlini  1 , Sven Gottschling  2 , Umut Yilmaz  3 , Sascha Meyer  4
Affiliations

Topiramate-induced nephrolithiasis

Eleni Z Giannopoulou et al. Clin Case Rep. 2015 Jun.

Abstract

Nephrolithiasis is a less common side effect of the antiepileptic drug topiramate. We report the case of a 3-year-old boy who presented to the emergency department with abdominal pain; examinations revealed a large calcification in the left kidney. Regular ultrasound examinations are recommended in children using topiramate.

Keywords: Abdominal pain; calcification; epilepsy.

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Figures

Figure 1
Figure 1
Plain abdominal X-ray demonstrating large left-sided kidney stone.
Figure 2
Figure 2
Large, fragmented kidney stone after open surgical removal.
See this image and copyright information in PMC

References

    1. Vega D, Maalouf NM. Sakhaee K. Increased propensity for calcium phosphate kidney stones with topiramate use. Expert Opin. Drug Saf. 2007;6:547–557. - PubMed
    1. Mahmoud AA, Rizk T, El-Bakri NK, Riaz M, Dannawi S. Al Tannir M. Incidence of kidney stones with topiramate treatment in pediatric patients. Epilepsia. 2011;52:1890–1893. - PubMed

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