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. 2015:2015:482342.
doi: 10.1155/2015/482342. Epub 2015 Jun 21.

A Rare Case of a Primary Squamous Cell Carcinoma of the Stomach Presenting as a Submucosal Mass

Wolf von Waagner  1 , Zhuo Wang  2 , Antonio I Picon  1
Affiliations

A Rare Case of a Primary Squamous Cell Carcinoma of the Stomach Presenting as a Submucosal Mass

Wolf von Waagner et al. Case Rep Surg. 2015.

Abstract

We report a case of a 70-year-old man, with a status after aortic valve replacement, who presented with melena and hypotension. On physical examination, he was hypotensive, but he responded to resuscitation. Esophagogastroduodenoscopy revealed a submucosal mass in the gastric fundus. Imaging of the chest, abdomen, and pelvis showed no evidence of local or distant metastasis. He underwent a partial diaphragmatic resection, gastrectomy, lymphadenectomy, and Roux-en-Y esophagojejunostomy. Pathology showed a gastric squamous cell carcinoma (SCC) invading the diaphragm, with negative margins of resection, and one positive perigastric lymph node. He received chemoradiation, but the patient expired 27 months after surgery.

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Figures

Figure 1
Figure 1
Esophagogastroduodenoscopy (EGD) showing an ulcerated submucosal mass in the fundus of the stomach (white arrow).
Figure 2
Figure 2
Computerized axial tomography scan with IV and PO contrast showing a mass in the gastric fundus (red arrow).
Figure 3
Figure 3
(a) Histopathological examination showing a moderately differentiated squamous cell carcinoma with keratinization (×100). Keratin pearl (black arrow). Mosaic cell arrangement with sharp border (red arrow). (b) Tumor invasion of the diaphragm (×100) (red arrow). (c) Lymphovascular invasion is present (×40) (black arrow). (d) Tumor with nerve invasion (×40) (black arrow).
Figure 4
Figure 4
Tumor cells showing strong coexpression of p63 (nuclear stain, brown) and cytokeratin 5/6 (membrane stain, red) (a) and negative expression of p16 (b), CD117 (c), and CK7 (d).
See this image and copyright information in PMC

References

    1. Wakabayashi H., Matsutani T., Fujita I., et al. A rare case of primary squamous cell carcinoma of the stomach and a review of the 56 cases reported in Japan. Journal of Gastric Cancer. 2014;14(1):58–62. doi: 10.5230/jgc.2014.14.1.58. - DOI - PMC - PubMed
    1. Muto M., Hasebe T., Muro K., et al. Primary squamous cell carcinoma of the stomach: a case report with a review of Japanese and Western literature. Hepato-Gastroenterology. 1999;46(29):3015–3018. - PubMed
    1. Bonnheim D. C., Sarac O. K., Fett W. Primary squamous cell carcinoma of the stomach. The American Journal of Gastroenterology. 1985;80(2):91–94. - PubMed
    1. Straus R., Heschel S., Fortmann D. J. Primary adenosquamous carcinoma of the stomach. A case report and review. Cancer. 1969;24(5):985–995. doi: 10.1002/1097-0142(196911)24:560;985::aid-cncr282024051862;3.0.co;2-4. - DOI - PubMed
    1. Schmidt C., Schmid A., Lüttges J. E., Kremer B., Henne-Bruns D. Primary squamous cell carcinoma of the stomach. Report of a case and review of literature. Hepato-Gastroenterology. 2001;48(40):1033–1036. - PubMed

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