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Comment
. 2015 Jul 16;162(2):243-245.
doi: 10.1016/j.cell.2015.06.064.

Optical Control of Microtubule Dynamics in Time and Space

Brian T Castle  1 , David J Odde  2
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Optical Control of Microtubule Dynamics in Time and Space

Brian T Castle et al. Cell. .
Free article

Abstract

Small molecule inhibitors of microtubule dynamics are widely used as cell biology research tools and clinically as cancer chemotherapeutics. By slight modification to the chemical structure of a known microtubule inhibitor, combretastatin A-4, Borowiak et al. develop a photoswitchable derivative that can be turned "on" and "off" with low-intensity light to spatially and temporally control microtubule dynamics.

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