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. 2015 Nov:27:423-429.
doi: 10.1016/j.ultsonch.2015.06.005. Epub 2015 Jun 9.

Ultrasonic-accelerated rapid protocol for the improved synthesis of pyrazoles

Nhlanhla Gracious Shabalala  1 , Ramakanth Pagadala  1 , Sreekantha B Jonnalagadda  2
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Free article

Ultrasonic-accelerated rapid protocol for the improved synthesis of pyrazoles

Nhlanhla Gracious Shabalala et al. Ultrason Sonochem. 2015 Nov.
Free article

Abstract

A simple, catalyst-free, green synthetic protocol is described for the one-pot synthesis of pyrazoles via multicomponent reaction of aromatic aldehydes, hydrazine monohydrate and ethyl acetoacetate and malononitrile/ammonium acetate in water under ultrasound irradiation. This protocol avoids traditional chromatography and purification steps and it affords highly selective conversion with no byproducts.

Keywords: Multicomponent reaction (MCR); One-pot synthesis; Pyrazole derivatives; Ultrasound; Water as solvent.

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