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. 2015 Sep 1;54(36):10596-9.
doi: 10.1002/anie.201503562. Epub 2015 Jul 17.

Direct Ruthenium-Catalyzed Hydrogenation of Carboxylic Acids to Alcohols

Xinjiang Cui  1 , Yuehui Li  1 , Christoph Topf  1 , Kathrin Junge  1 , Matthias Beller  2
Affiliations

Direct Ruthenium-Catalyzed Hydrogenation of Carboxylic Acids to Alcohols

Xinjiang Cui et al. Angew Chem Int Ed Engl. .

Abstract

The "green" reduction of carboxylic acids to alcohols is a challenging task in organic chemistry. Herein, we describe a general protocol for generation of alcohols by catalytic hydrogenation of carboxylic acids. Key to success is the use of a combination of Ru(acac)3, triphos and Lewis acids. The novel method showed broad substrate tolerance and a variety of aliphatic carboxylic acids including biomass-derived compounds can be smoothly reduced.

Keywords: alcohols; carboxylic acids; homogeneous catalysis; hydrogenation; ruthenium.

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