Granulocyte-colony stimulating factor as a treatment for diabetic neuropathy in rat

Kyung-Soo Kim¹, Yi-Sun Song², Jiyong Jin³, Jun-Ho Joe², Byung-Im So², Jun-Young Park², Cheng-Hu Fang³, Mi Jung Kim⁴, Youl-Hee Cho⁵, Sejin Hwang⁶, Young-Suck Ro⁷, Hyuck Kim⁸, You-Hern Ahn⁹, Hak-Joon Sung¹⁰, Jung-Joon Sung¹¹, Sung-Hye Park¹², Stuart A Lipton¹³

Affiliations

¹ Division of Cardiology, Hanyang University College of Medicine, Seoul, 133-792, South Korea; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, 133-792, South Korea. Electronic address: kskim@hanyang.ac.kr.
² Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, 133-792, South Korea.
³ Division of Cardiology, Yanbian University, Yanji, 133000, China.
⁴ Department of Rehabilitation Medicine, Hanyang University College of Medicine, Seoul, 133-792, South Korea.
⁵ Department of Medical Genetics, Hanyang University, Seoul, 133-792, South Korea.
⁶ Department of Anatomy and Cell Biology, Hanyang University, Seoul, 133-792, South Korea.
⁷ Department of Dermatology, Hanyang University College of Medicine, Seoul, 133-792, South Korea.
⁸ Department of Cardiovascular Surgery, Hanyang University College of Medicine, Seoul, 133-792, South Korea.
⁹ Department of Endocrinology & Metabolism, Hanyang University College of Medicine, Seoul, 133-792, South Korea.
¹⁰ Department of Biomedical Engineering, Vanderbilt University, VU Station B, Box 351631 Nashville, TN 37235, USA.
¹¹ Department of Neurology, Seoul National University College of Medicine, Seoul, 110-744, South Korea.
¹² Department of Pathology, Seoul National University College of Medicine, Seoul, 110-744, South Korea.
¹³ Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, CA, USA; Department of Neurosciences, School of Medicine, University of California at San Diego, CA, USA. Electronic address: slipton@ucsd.edu.

PMID: 26190836
DOI: 10.1016/j.mce.2015.07.014

Granulocyte-colony stimulating factor as a treatment for diabetic neuropathy in rat

Kyung-Soo Kim et al. Mol Cell Endocrinol. 2015.

. 2015 Oct 15:414:64-72.

doi: 10.1016/j.mce.2015.07.014. Epub 2015 Jul 17.

Authors

Affiliations

¹ Division of Cardiology, Hanyang University College of Medicine, Seoul, 133-792, South Korea; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, 133-792, South Korea. Electronic address: kskim@hanyang.ac.kr.
² Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, 133-792, South Korea.
³ Division of Cardiology, Yanbian University, Yanji, 133000, China.
⁴ Department of Rehabilitation Medicine, Hanyang University College of Medicine, Seoul, 133-792, South Korea.
⁵ Department of Medical Genetics, Hanyang University, Seoul, 133-792, South Korea.
⁶ Department of Anatomy and Cell Biology, Hanyang University, Seoul, 133-792, South Korea.
⁷ Department of Dermatology, Hanyang University College of Medicine, Seoul, 133-792, South Korea.
⁸ Department of Cardiovascular Surgery, Hanyang University College of Medicine, Seoul, 133-792, South Korea.
⁹ Department of Endocrinology & Metabolism, Hanyang University College of Medicine, Seoul, 133-792, South Korea.
¹⁰ Department of Biomedical Engineering, Vanderbilt University, VU Station B, Box 351631 Nashville, TN 37235, USA.
¹¹ Department of Neurology, Seoul National University College of Medicine, Seoul, 110-744, South Korea.
¹² Department of Pathology, Seoul National University College of Medicine, Seoul, 110-744, South Korea.
¹³ Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, CA, USA; Department of Neurosciences, School of Medicine, University of California at San Diego, CA, USA. Electronic address: slipton@ucsd.edu.

PMID: 26190836
DOI: 10.1016/j.mce.2015.07.014

Abstract

Effective treatment of diabetic neuropathy (DN) remains unsolved. We serendipitously observed dramatic relief of pain in several patients with painful DN receiving granulocyte-colony stimulating factor (G-CSF). The aim of this study was to determine if G-CSF could treat DN in an animal model and to ascertain its mechanism of action. In a rodent model of DN, G-CSF dramatically recovered nerve function, retarded histological nerve changes and increased the expression of neurotrophic factors within nerve. A sex-mismatched bone marrow transplantation (BMT) study revealed that G-CSF treatment increased the abundance of bone marrow (BM)-derived cells in nerves damaged by DN. However, we did not observe evidence of transdifferentiation or cell fusion of BM-derived cells. The beneficial effects of G-CSF were dependent on the integrity of BM. In conclusion, G-CSF produced a therapeutic effect in a rodent model of DN, which was attributed, at least in part, to the actions of BM-derived cells.

Keywords: Bone marrow-derived cells; Diabetic neuropathy; Granulocyte-colony stimulating factor.

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Granulocyte-colony stimulating factor as a treatment for diabetic neuropathy in rat

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Granulocyte-colony stimulating factor as a treatment for diabetic neuropathy in rat

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Medical