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Review
. 2015 Jul 2:3:56.
doi: 10.3389/fped.2015.00056. eCollection 2015.

Cronobacter Species Contamination of Powdered Infant Formula and the Implications for Neonatal Health

Gautam Kalyantanda  1 , Lyudmila Shumyak  1 , Lennox Kenneth Archibald  2
Affiliations
Review

Cronobacter Species Contamination of Powdered Infant Formula and the Implications for Neonatal Health

Gautam Kalyantanda et al. Front Pediatr. .

Abstract

Cronobacter is a class of Enterobacteriaceae that cause infections in neonates, especially those born prematurely. Over 90% of these infections have been linked epidemiologically to powdered infant formula (PIF). Contamination of PIF can occur at manufacture, reconstitution, or storage of reconstituted product. Intrinsic properties that enable Cronobacter to cause disease include resistance to heat, ultraviolet radiation, oxygen radicals, stomach acids, and pasteurization; an ability to utilize sialic acid (a nutrition additive to PIF that facilitates the organism's growth and survival), and an exceptional affinity for biofilms in enteral feeding tubes. As part of ongoing endeavors to reduce the incidence of neonatal PIF-associated Cronobacter infections, the World Health Organization and the US Food and Drug Administration have established guidelines for PIF production, preparation for infant feeding, and storage of reconstituted product.

Keywords: Cronobacter; Enterobacter; necrotizing enterocolitis; neonatal meningitis; neonatal mortality; neonatal sepsis; powdered infant formula; sakazakii.

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References

    1. Chenu JW, Cox JM. Cronobacter (‘Enterobacter sakazakii’): current status and future prospects. Lett Appl Microbiol (2009) 49(2):153–9.10.1111/j.1472-765X.2009.02651.x - DOI - PubMed
    1. Caubilla-Barron J, Hurrell E, Townsend S, Cheetham P, Loc-Carrillo C, Fayet O, et al. Genotypic and phenotypic analysis of Enterobacter sakazakii strains from an outbreak resulting in fatalities in a neonatal intensive care unit in France. J Clin Microbiol (2007) 45(12):3979–85.10.1128/JCM.01075-07 - DOI - PMC - PubMed
    1. Osaili T, Forsythe S. Desiccation resistance and persistence of Cronobacter species in infant formula. Int J Food Microbiol (2009) 136(2):214–20.10.1016/j.ijfoodmicro.2009.08.006 - DOI - PubMed
    1. Holy O, Forsythe S. Cronobacter spp. as emerging causes of healthcare-associated infection. J Hosp Infect (2014) 86(3):169–77.10.1016/j.jhin.2013.09.011 - DOI - PubMed
    1. Archibald LK, Jarvis WR. Health care-associated infection outbreak investigations by the centers for disease control and prevention, 1946-2005. Am J Epidemiol (2011) 174(11 Suppl):S47–64.10.1093/aje/kwr310 - DOI - PubMed