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. 1989 Dec;33(12):2149-51.
doi: 10.1128/AAC.33.12.2149.

Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol

T S Lin  1 , R Schinazi, B P Griffith, E M August, B F Eriksson, D K Zheng, L A Huang, W H Prusoff
Affiliations

Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol

T S Lin et al. Antimicrob Agents Chemother. 1989 Dec.

Abstract

The (-) enantiomer of gossypol but not the (+) enantiomer had good antiviral activity in peripheral blood mononuclear cells against human immunodeficiency virus type 1 at a concentration more than 20-fold lower than that required for cytotoxicity; however, in H9 cells the (-) enantiomer, although more potent as an antiviral agent, was more cytotoxic.

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References

    1. Antiviral Res. 1988 Apr;9(3):163-75 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Jul;85(14):5230-4 - PubMed
    1. Antimicrob Agents Chemother. 1988 Dec;32(12):1784-7 - PubMed
    1. Antimicrob Agents Chemother. 1989 Jan;33(1):115-7 - PubMed
    1. J Chem Soc Chem Commun. 1985 Feb 1;(3):168-9 - PubMed

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