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. 1989 Dec;55(12):3140-2.
doi: 10.1128/aem.55.12.3140-3142.1989.

Aromatic hydroxylation and sulfation of 5-hydroxyflavone by Streptomyces fulvissimus

A R Ibrahim  1 , Y J Abul-Hajj
Affiliations

Aromatic hydroxylation and sulfation of 5-hydroxyflavone by Streptomyces fulvissimus

A R Ibrahim et al. Appl Environ Microbiol. 1989 Dec.

Abstract

The conversion of 5-hydroxyflavone by various microorganisms was studied. Among them, Streptomyces fulvissimus was the sole microbe which produced a new polar metabolite from 5-hydroxyflavone in addition to 5,4-dihydoxy- and 5,3,4-trihydroxyflavone. The structure of this polar metabolite was determined to be 5,4-dihydroxyflavone-4-sulfate on the basis of mass, infrared, and nuclear magnetic resonance spectroscopies. These results demonstrate that S. fulvissimus catalyzes sulfation at the 4 position of 4,5-dihydroxyflavone.

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