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Review
. 2015 Jul 16;12(7):8187-97.
doi: 10.3390/ijerph120708187.

PM2.5 and Cardiovascular Diseases in the Elderly: An Overview

Chenchen Wang  1 , Yifan Tu  2 , Zongliang Yu  3 , Rongzhu Lu  4   5
Affiliations
Review

PM2.5 and Cardiovascular Diseases in the Elderly: An Overview

Chenchen Wang et al. Int J Environ Res Public Health. .

Abstract

Background: Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in the elderly and the ambient concentration of PM2.5 has been associated with several cardiovascular diseases.

Methods: We describe the present state of planetary air pollution, analyze epidemiological studies linking PM2.5 and CVD, and discuss multiple pathophysiological mechanisms linking PM2.5 and CVD.

Results: A few epidemiological studies show that the elderly appear specifically susceptible to adverse cardiovascular effects triggered by PM2.5 exposure. Plausible pathophysiological mechanisms include inflammatory dysfunction, oxidative stress, abnormal activation of the hemostatic system and disturbance of the autonomic nervous system.

Conclusions: An in-depth knowledge of the chemical compounds, pathophysiological mechanisms, and epidemiological studies of PM2.5 are recommended to understand this important and modifiable factor contributing to geriatric CVD burden. We offer public health recommendations to reduce this preventable cause of disease and death.

Keywords: Cardiovascular disease (CVD); PM2.5; susceptibility; the elderly.

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Figures

Figure 1
Figure 1
The global distribution of PM2.5 averaged over 2001–2006 (Credit: Dalhousie University, Aaron van Donkelaar, http://www.nasa.gov/topics/earth/features/healthappoing.html).
See this image and copyright information in PMC

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