Large-Volume Microfluidic Cell Sorting for Biomedical Applications

Abstract

Microfluidic cell-separation technologies have been studied for almost two decades, but the limited throughput has restricted their impact and range of application. Recent advances in microfluidics enable high-throughput cell sorting and separation, and this has led to various novel diagnostic and therapeutic applications that previously had been impossible to implement using microfluidics technologies. In this review, we focus on recent progress made in engineering large-volume microfluidic cell-sorting methods and the new applications enabled by them.

Keywords: blood transfusion; cell sorting; circulating cancer cells; high-throughput; inertial; large-volume microfluidic; separation; sepsis.