B cells in the aging immune system: time to consider B-1 cells
- PMID: 26194480
- PMCID: PMC4679494
- DOI: 10.1111/nyas.12825
B cells in the aging immune system: time to consider B-1 cells
Abstract
The investigation of immune senescence has uncovered many changes in B cell development, maintenance, and function with increasing age. However, most of these studies have focused on conventional B cell subsets in the spleen. The B-1 cell subset is an essential arm of the innate immune system, which in general has been understudied in terms of immune senescence. Here, we review what is currently known about B cells during aging and go on to describe why B-1 cell biology is an important component of the aging immune system in the context of diseases that most affect the aged population.
Keywords: B cells; B-1 cells; aging; senescence.
© 2015 New York Academy of Sciences.
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