Chromosome Segregation: A Spatial Code to Correct Kinetochore-Microtubule Attachments
- PMID: 26196485
- DOI: 10.1016/j.cub.2015.05.056
Chromosome Segregation: A Spatial Code to Correct Kinetochore-Microtubule Attachments
Abstract
Erroneous kinetochore-microtubule interactions must be detected and corrected before a cell enters anaphase to prevent chromosome mis-segregation. Two new studies describe an Aurora A-mediated error correction mechanism based on the spatial position of a chromosome within the mitotic spindle.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Comment on
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Spatial Regulation of Kinetochore Microtubule Attachments by Destabilization at Spindle Poles in Meiosis I.Curr Biol. 2015 Jul 20;25(14):1835-41. doi: 10.1016/j.cub.2015.05.013. Epub 2015 Jul 9. Curr Biol. 2015. PMID: 26166779 Free PMC article.
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Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway.Curr Biol. 2015 Jul 20;25(14):1842-51. doi: 10.1016/j.cub.2015.06.021. Epub 2015 Jul 9. Curr Biol. 2015. PMID: 26166783 Free PMC article.
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