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Comment
. 2015 Jul 21;13(7):e1002201.
doi: 10.1371/journal.pbio.1002201. eCollection 2015 Jul.

Tuning up STAT1

Caitlin Sedwick  1
Affiliations
Comment

Tuning up STAT1

Caitlin Sedwick. PLoS Biol. .

Abstract

STAT1 is a key regulator of diverse immune responses, but the basis of this diversity is poorly understood; a new study uses a parasite's ability to block STAT1 to identify the host protein TLX as a modulator of STAT1 activity in the brain. Read the accompanying Research Article.

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Conflict of interest statement

The author has declared that no competing interests exist.

Figures

Fig 1
Fig 1. T. gondii cysts containing thousands of parasites (in red) can develop in many vertebrate tissues, such as the mouse brain.
Image credit: Jitender P. Dubey.
See this image and copyright information in PMC

Comment on

References

    1. Beiting DP, Hidano S, Baggs JE, Geskes JM, Fang Q, Wherry EJ, et al. The orphan nuclear receptor TLX is an enhancer of STAT1-mediated transcription and immunity to Toxoplasma gondii . PLoS Biol. 2015;13(7): e1002200. - PMC - PubMed

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