Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jul 20;18(4 Suppl 3):19979.
doi: 10.7448/IAS.18.4.19979. eCollection 2015.

Pre-exposure prophylaxis in Southern Africa: feasible or not?

Affiliations

Pre-exposure prophylaxis in Southern Africa: feasible or not?

Willem Daniel François Venter et al. J Int AIDS Soc. .

Abstract

Introduction: Southern and Eastern Africa bear the brunt of the AIDS epidemic, and current prevention interventions remain inadequate. Antiretroviral-based pre-exposure prophylaxis (PrEP) is gaining momentum as an effective prevention intervention.

Discussion: Discussions have been started on how this strategy could be employed in Africa such that the populations most in need can be reached urgently for the greatest impact. This requires the selection of specific risk groups and service environments in which PrEP can be distributed safely and cost effectively while being mindful of any ethical issues.

Conclusions: Given the need for an integrated public health approach to this, a number of potential populations and opportunities for PrEP distribution exist and are discussed in this commentary.

Keywords: AIDS; HIV; PrEP; South Africa.

PubMed Disclaimer

References

    1. Bekker LG, Venter F, Cohen K, Goemare E, Van Cutsem G, Boulle A, et al. Provision of antiretroviral therapy in South Africa: the nuts and bolts. Antivir Ther. 2014;19(Suppl 3):105–16. doi: 10.3851/IMP2905. - DOI - PubMed
    1. What works for women and girls. [cited 2014 Nov 6]. Available from: http://www.whatworksforwomen.org.
    1. Pruden H, Watts C, Vickerman P, Bobrova N, Heise L, Ogungbemi M, et al. Can the UNAIDS modes of transmission model be improved? A comparison of the original and revised model projections using data from a setting in west Africa. AIDS. 2013;27:2623–35. - PMC - PubMed
    1. Kiwanuka N, Ssetaala A, Nalutaaya A, Mpendo J, Wambuzi M, Nanvubya A, et al. High incidence of HIV-1 infection in a general population of fishing communities around Lake Victoria, Uganda. PLoS One. 2014;9(5):94932. doi: 10.1371/journal.pone.00949325. - DOI - PMC - PubMed
    1. Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, Wangisi J, et al. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med. 2012;367:399–410. - PMC - PubMed

Publication types

Substances