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Editorial
. 2015 Jul 20;18(4 Suppl 3):20527.
doi: 10.7448/IAS.18.4.20527. eCollection 2015.

PrEP Implementation Science: State-of-the-Art and Research Agenda

Carlos F Cáceres, Kenneth H Mayer, Rachel Baggaley, Kevin R O'Reilly
Editorial

PrEP Implementation Science: State-of-the-Art and Research Agenda

Carlos F Cáceres et al. J Int AIDS Soc. .
No abstract available

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Figures

Figure 1
Figure 1
The reported number of institutional births each month in Gaza Province and Cabo Delgado Province, Mozambique.
Figure 2
Figure 2
Modelled prevalence and incidence. Model calibration to prevalence (a); modelled incidence among men and women (b); modelled incidence among partners of miners (c).
Figure 3
Figure 3
The influence of prioritizing PrEP on the estimated cost per infection averted.
Figure 4
Figure 4
The (a) influence of adherence on impact and (b) influence of adherence and cost on cost per infection averted.
Figure 5
Figure 5
The influence of different assumptions regarding the level of transmission occurring between miners and their partners in December.
Figure 1
Figure 1
Additional PrEP programme costs by resource type. The allocation of costs by resource type for the intervention “As Studied” (a) and in the “Ministry of Health” (b). “Ministry of Health” includes public-sector salaries, fewer laboratory tests, less expensive medication and task-shifting.
Figure 2
Figure 2
Annual incremental cost per couple by annual number of couples enrolled. The costs are based on the Ministry of Health scenario with public-sector salaries, fewer laboratory tests, less expensive medication and task-shifting. The clinic capacity assumes a screen-to-enrol ratio of 1.37, and 97% retention of enrolled couples over 12 months.
Figure 3
Figure 3
Sensitivity of the ICER per DALY (a) and HIV infection (b) averted for the high-risk serodiscordant couples PrEP programme. The base case ICER is $5354 per DALY averted and $1340 per HIV infection averted.
Figure 1
Figure 1
Annual new HIV infections in Thailand by risk category, 1988–2015. Adapted from Ref. [12].
Figure 1
Figure 1
Proportion of all AIDS cases occurring in young men who have sex with men according to age in Brazil from 2004 to 2013. Source: Brazilian Ministry of Health. Department of STDs, AIDS and Viral Hepatitis [16].
Figure 2
Figure 2
The cascade of HIV care in Brazil in 2013. Source: Brazilian Ministry of Health. Department of STDs, AIDS and Viral Hepatitis [16].
Figure 3
Figure 3
Number of individuals receiving non-occupational post-exposure prophylaxis (nPEP) from 2012 to 2014. Source: Brazilian Ministry of Health. Department of STDs, AIDS and Viral Hepatitis [16].
Figure 1
Figure 1
Regulatory approval in trial host countries for daily TFD/FTC. Permission to use granted by AVAC.
See this image and copyright information in PMC

References

    1. Cáceres CF, Koechlin F, Goicochea P, Sow P-S, O'Reilly K, Mayer K, et al. The promises and challenges of pre-exposure prophylaxis as part of the emerging paradigm of combination HIV prevention. J Int AIDS Soc. 2015;18 19949, doi: http://dx.doi.org/10.7448/IAS.18.4.19949. - DOI - PMC - PubMed
    1. Cremin I, Morales F, Jewell BL, O'Reilly K, Hallett TB. Seasonal PrEP for partners of migrant miners in southern Mozambique: a highly focused PrEP intervention. J Int AIDS Soc. 2015;18 19946, doi: http://dx.doi.org/10.7448/IAS.18.4.19946. - DOI - PMC - PubMed
    1. Ying R, Heffron R, Celum C, Baeten JM, Katabira E, Bulya N, et al. Cost-effectiveness of pre-exposure prophylaxis targeted to high-risk serodiscordant couples as a bridge to sustained ART use in Kampala, Uganda. J Int AIDS Soc. 2015;18 20013, doi: http://dx.doi.org/10.7448/IAS.18.4.20013. - DOI - PMC - PubMed
    1. Auerbach JD, Hoppe TA. Beyond “getting drugs into bodies:” Social science perspectives on pre-exposure prophylaxis for HIV. J Int AIDS Soc. 2015;18 19983, doi: http://dx.doi.org/10.7448/IAS.18.4.19983. - DOI - PMC - PubMed
    1. Venter F, Cowan F, Black V, Rebe K, Bekker LG. Pre exposure prophylaxis in Southern Africa: feasible or not? J Int AIDS Soc. 2015;18 19979, doi: http://dx.doi.org/10.7448/IAS.18.4.19979. - DOI - PMC - PubMed

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