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Review
. 2015 Sep;99(17):6997-7008.
doi: 10.1007/s00253-015-6818-4. Epub 2015 Jul 22.

Antiviral activities of whey proteins

Tzi Bun Ng  1 , Randy Chi Fai Cheung, Jack Ho Wong, Yan Wang, Denis Tsz Ming Ip, David Chi Cheong Wan, Jiang Xia
Affiliations
Review

Antiviral activities of whey proteins

Tzi Bun Ng et al. Appl Microbiol Biotechnol. 2015 Sep.

Abstract

Milk contains an array of proteins with useful bioactivities. Many milk proteins encompassing native or chemically modified casein, lactoferrin, alpha-lactalbumin, and beta-lactoglobulin demonstrated antiviral activities. Casein and alpha-lactalbumin gained anti-HIV activity after modification with 3-hydroxyphthalic anhydride. Many milk proteins inhibited HIV reverse transcriptase. Bovine glycolactin, angiogenin-1, lactogenin, casein, alpha-lactalbumin, beta-lactoglobulin, bovine lactoferrampin, and human lactoferrampin inhibited HIV-1 protease and integrase. Several mammalian lactoferrins prevented hepatitis C infection. Lactoferrin, methylated alpha-lactalbumin and methylated beta-lactoglobulin inhibited human cytomegalovirus. Chemically modified alpha-lactalbumin, beta-lactoglobulin and lysozyme, lactoferrin and lactoferricin, methylated alpha-lactalbumin, methylated and ethylated beta-lactoglobulins inhibited HSV. Chemically modified bovine beta-lactoglobulin had antihuman papillomavirus activity. Beta-lactoglobulin, lactoferrin, esterified beta-lactoglobulin, and esterified lactoferrindisplayed anti-avian influenza A (H5N1) activity. Lactoferrin inhibited respiratory syncytial virus, hepatitis B virus, adenovirus, poliovirus, hantavirus, sindbis virus, semliki forest virus, echovirus, and enterovirus. Milk mucin, apolactoferrin, Fe(3+)-lactoferrin, beta-lactoglobulin, human lactadherin, bovine IgG, and bovine kappa-casein demonstrated antihuman rotavirus activity.

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Figures

Fig. 1
Fig. 1
Different antiviral actions of milk proteins
See this image and copyright information in PMC

References

    1. Alfajaro MM, Rho MC, Kim HJ, Park JG, Kim DS, Hosmillo M, Son KY, Lee JH, Park SI, Kang MI, Ryu YB, Park KH, Oh HM, Lee SW, Park SJ, Lee WS, Cho KO. Anti-rotavirus effects by combination therapy of stevioside and Sophora flavescens extract. Res Vet Sci. 2014;96(3):567–575. doi: 10.1016/j.rvsc.2014.03.011. - DOI - PubMed
    1. Almehdar HA, El-Fakharany EM, Uversky VN, Redwan EM (2015) Disorder in milk proteins: structure, functional disorder, and biocidalpotentials of lactoperoxidase. Curr Protein Pept Sci - PubMed
    1. Ammendolia MG, Agamennone M, Pietrantoni A, Lannutti F, Siciliano RA, DeGiulio B, Amici C, Superti F. Bovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus. Pathog Glob Health. 2012;106(1):12–19. doi: 10.1179/2047773212Y.0000000004. - DOI - PMC - PubMed
    1. Andersen JH, Jenssen H, Gutteberg TJ. Lactoferrin and lactoferricin inhibit Herpes simplex 1 and 2 infection andexhibit synergy when combined with acyclovir. Antiviral Res. 2003;58(3):209–215. doi: 10.1016/S0166-3542(02)00214-0. - DOI - PubMed
    1. Andersen JH, Jenssen H, Sandvik K, Gutteberg TJ. Anti-HSV activity of lactoferrin and lactoferricin is dependent on the presence of heparin sulphate at the cell surface. J Med Virol. 2004;74(2):262–271. doi: 10.1002/jmv.20171. - DOI - PubMed

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