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Randomized Controlled Trial
. 2015 Aug 15:285:143-6.
doi: 10.1016/j.jneuroim.2015.06.004. Epub 2015 Jun 16.

The effect of proinflammatory cytokines in Cognitive Behavioral Therapy

Fernanda Pedrotti Moreira  1 , Taiane de Azevedo Cardoso  1 , Thaíse Campos Mondin  1 , Luciano Dias de Mattos Souza  1 , Ricardo Silva  1 , Karen Jansen  1 , Jean Pierre Oses  1 , Carolina David Wiener  2
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Free article
Randomized Controlled Trial

The effect of proinflammatory cytokines in Cognitive Behavioral Therapy

Fernanda Pedrotti Moreira et al. J Neuroimmunol. .
Free article

Abstract

Major depressive disorder (MDD) is a debilitating disorder and its pathophysiology is associated with deregulation of the immune system. We investigated the changes in circulating levels of proinflammatory cytokines (specifically IL-6 and TNF-α) measured by the ELISA kit in two psychotherapeutic interventions for MDD: Narrative Cognitive Therapy (NCT) and Cognitive Behavioral Therapy (CBT). This is a randomized clinical trial including 97 individuals (18 to 29years-old) with MDD. In CBT there was a significant difference in serum levels of IL-6 and TNF-α, therefore indicating that CBT was more effective than NCT on serum levels proinflammatory cytokines.

Keywords: Cognitive Behavioral Therapy (CBT); Depression; Interleukin-6 (IL-6); Proinflammatory cytokines; Tumor necrosis factor alpha (TNF-α).

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