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Comment
. 2015 Jul 21;43(1):5-6.
doi: 10.1016/j.immuni.2015.07.002.

Caught Off Center: Rethinking the Requirements for Antibody Affinity Maturation

Lauren E Higdon  1 , Michael P Cancro  2
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Caught Off Center: Rethinking the Requirements for Antibody Affinity Maturation

Lauren E Higdon et al. Immunity. .
Free article

Abstract

Antibody affinity maturation involves selective survival of high affinity B cells and is thought to require the germinal center (GC) microenvironment. In this issue of Immunity, Di Niro et al. (2015) challenge this view, showing that low affinity B cells initiate Salmonella responses and affinity mature outside of GCs.

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