Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Sep;17(9):42.
doi: 10.1007/s11912-015-0465-x.

High-Dose Chemotherapy and Autologous Stem Cell Transplant in Older Patients with Lymphoma

Oscar B Lahoud  1 , Craig S Sauter, Paul A Hamlin, Parastoo Bahrami Dahi
Affiliations
Review

High-Dose Chemotherapy and Autologous Stem Cell Transplant in Older Patients with Lymphoma

Oscar B Lahoud et al. Curr Oncol Rep. 2015 Sep.

Abstract

High-dose chemotherapy followed by autologous hematopoietic stem cell transplant (HDT/ASCT) can improve survival in patients with lymphoma. Limited experience is available on the safety and efficacy of HDT/ASCT in elderly patients. In this article, we review the published data on the role of HDT/ASCT in management of lymphoma in older patients. Based on available data, evaluation of comorbidities, functional status, and comprehensive geriatric assessment (CGA) will help identify those who can benefit most from this intervention. Prospective clinical trials focusing on HDT/ASCT in older patients with lymphoma are needed to establish optimal management protocols in this select population.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Oscar B. Lahoud, Craig S. Sauter, Paul A. Hamlin, and Parastoo Bahrami Dahi declare that they have no conflict of interest.

References

    1. Smith BD, Smith GL, Hurria A, et al. Future of cancer incidence in the United States: burdens upon an aging, changing nation. J Clin Oncol. 2009;27:2758–65. - PubMed
    1. Mc FW, Granville NB, Dameshek W. Autologous bone marrow infusion as an adjunct in therapy of malignant disease. Blood. 1959;14:503–21. - PubMed
    1. Clifford P, Clift RA, Duff JK. Nitrogen-mustard therapy combined with autologous marrow infusion. Lancet. 1961;1:687–90. - PubMed
    1. Pegg DE. A quantitative study of bone marrow grafting: implications for human bone marrow infusion. Br J Cancer. 1962;16:400–16. - PMC - PubMed
    1. Kurnick NB. Autologous and isologous bone marrow storage and infusion in the treatment of myelo-suppresson. Transfusion. 1962;2:178–87. - PubMed

MeSH terms