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. 2015 Oct;53(10):3341-4.
doi: 10.1128/JCM.01017-15. Epub 2015 Jul 22.

Large Nosocomial Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Traced to Clonal Expansion of an mgrB Deletion Mutant

Tommaso Giani  1 , Fabio Arena  1 , Guendalina Vaggelli  2 , Viola Conte  1 , Adriana Chiarelli  1 , Lucia Henrici De Angelis  1 , Rossella Fornaini  3 , Maddalena Grazzini  4 , Fabrizio Niccolini  4 , Patrizia Pecile  2 , Gian Maria Rossolini  5
Affiliations

Large Nosocomial Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Traced to Clonal Expansion of an mgrB Deletion Mutant

Tommaso Giani et al. J Clin Microbiol. 2015 Oct.

Abstract

We describe a large hospital outbreak (93 bloodstream infections) of colistin-resistant Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates which was mirrored by increased colistin consumption. The outbreak was mostly traced to the clonal expansion of an mgrB deletion mutant of an ST512 strain that produced KPC-3.

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References

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