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Comment
. 2015 Oct;89(19):10130-2.
doi: 10.1128/JVI.01226-15. Epub 2015 Jul 22.

Puzzling Origins of the Ebola Outbreak in the Democratic Republic of the Congo, 2014

Tommy Tsan-Yuk Lam  1 , Huachen Zhu  1 , Yee Ling Chong  2 , Edward C Holmes  3 , Yi Guan  4
Affiliations
Comment

Puzzling Origins of the Ebola Outbreak in the Democratic Republic of the Congo, 2014

Tommy Tsan-Yuk Lam et al. J Virol. 2015 Oct.
No abstract available

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Figures

FIG 1
FIG 1
Phylogeny and regression of root-to-tip genetic distances against time of sampling for ZEBOV 1976-2014. (A) Maximum-likelihood phylogeny estimated from the nearly complete genome sequences of 32 ZEBOVs, including those (COD/2014/Boende-Lokolia, COD/2014/Lomela-Lokolia16, COD/2014/Lomela-Lokolia17, and COD/2014/Lomela-Lokolia19; strain names in red) collected from the 2014 outbreak in the Democratic Republic of the Congo (COD). Branch supports (shown at selected nodes) were assessed by bootstrap analysis (1,000 replicates). The boxes on the left show amino acid changes in the NP, VP35, VP40, and GP proteins that have occurred on specific branches, as indicated by dashed lines. Positions are numbered from the first residue of each protein. (B) The genetic distances from the root of the tree to each sequence (tip) are plotted against their year of sampling. Solid and dashed lines are the linear regression fits and the 95% prediction bands for the data points excluding COD/2014 sequences. The COD/2014 ZEBOV sequences (red dots) fall below the expected genetic distance, indicating that they have evolved markedly more slowly. (C and D) Similar observations made using the GP and NP genes, which include more sequences with different time points.
See this image and copyright information in PMC

Comment on

  • Ebola virus disease in the Democratic Republic of Congo.
    Maganga GD, Kapetshi J, Berthet N, Kebela Ilunga B, Kabange F, Mbala Kingebeni P, Mondonge V, Muyembe JJ, Bertherat E, Briand S, Cabore J, Epelboin A, Formenty P, Kobinger G, González-Angulo L, Labouba I, Manuguerra JC, Okwo-Bele JM, Dye C, Leroy EM. Maganga GD, et al. N Engl J Med. 2014 Nov 27;371(22):2083-91. doi: 10.1056/NEJMoa1411099. Epub 2014 Oct 15. N Engl J Med. 2014. PMID: 25317743

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