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. 2015 Jun 30;6(18):16766-73.
doi: 10.18632/oncotarget.4414.

Distinctive clinical characteristics of malignant mesothelioma in young patients

Anish Thomas  1 , Yuanbin Chen  1 , Tinghui Yu  2 , Ammara Gill  3 , Vinay Prasad  4
Affiliations

Distinctive clinical characteristics of malignant mesothelioma in young patients

Anish Thomas et al. Oncotarget. .

Abstract

Although considered a disease of the elderly, a subset of patients with mesothelioma are young (<40 years). The goal of this study was to understand their characteristics and outcomes. The Surveillance, Epidemiology, and End Results (SEER) database was used to extract mesothelioma cases (1990-2010). We modeled Kaplan-Meyer survival curves stratified by site of disease, and age of presentation. 2% (207 of 12345) of mesothelioma patients are young. Sex distribution is comparable among the young (51% males, 49% females); males predominated (78%, 22%) in the older cohort. Frequency of pleural and peritoneal mesothelioma are similar in the young (47%, 48% respectively); pleural disease predominated in the old (90%, 9%). Cancer-directed surgeries are more frequent in the young. Regardless of histologic subtype, young patients with pleural (11 vs. 8 months) and peritoneal (not reached vs. 10 months) mesothelioma had significantly improved overall survival. In multivariate analysis, younger age was an independent prognostic factor. Although rare, mesothelioma do occur in the young; their characteristics are distinct from those of older patients. Further studies are needed to understand the interplay between genetic susceptibility and mineral fiber carcinogenesis in the pathogenesis of mesothelioma in the young.

Keywords: SEER analysis; asbestos; incidence among the young; mesothelioma.

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Conflict of interest statement

CONFLICTS OF INTEREST

None of the authors have potential conflicts of interest.

Figures

Figure 1
Figure 1. Overall survival of young and old patients by primary site of origin of mesothelioma
See this image and copyright information in PMC

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