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Comment
. 2015 Nov 15;21(22):4999-5001.
doi: 10.1158/1078-0432.CCR-15-1146. Epub 2015 Jul 22.

"Braking" the Cycle of Resistance in Endocrine Therapy for Breast Cancer

Angela DeMichele  1 , Lewis A Chodosh  2
Affiliations
Comment

"Braking" the Cycle of Resistance in Endocrine Therapy for Breast Cancer

Angela DeMichele et al. Clin Cancer Res. .

Abstract

Endocrine resistance leads to recurrence and death from breast cancer. Animal models of endocrine resistance enable preclinical identification of efficacious therapeutic combinations and further our understanding of resistance. This strategy provides new insights into optimally targeting interactions between estrogen receptor (ESR-1) activity and the cell cycle by CDK4/6 inhibitors. See related article by Wardell et al., p. 5121.

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