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. 2015 Jun 18;6(7):2609-23.
doi: 10.1364/BOE.6.002609. eCollection 2015 Jul 1.

In-vivo multilaboratory investigation of the optical properties of the human head

Andrea Farina  1 , Alessandro Torricelli  2 , Ilaria Bargigia  3 , Lorenzo Spinelli  1 , Rinaldo Cubeddu  2 , Florian Foschum  4 , Marion Jäger  4 , Emanuel Simon  4 , Oliver Fugger  4 , Alwin Kienle  4 , Fabrizio Martelli  5 , Paola Di Ninni  5 , Giovanni Zaccanti  5 , Daniel Milej  6 , Piotr Sawosz  6 , Michał Kacprzak  6 , Adam Liebert  6 , Antonio Pifferi  7
Affiliations

In-vivo multilaboratory investigation of the optical properties of the human head

Andrea Farina et al. Biomed Opt Express. .

Abstract

The in-vivo optical properties of the human head are investigated in the 600-1100 nm range on different subjects using continuous wave and time domain diffuse optical spectroscopy. The work was performed in collaboration with different research groups and the different techniques were applied to the same subject. Data analysis was carried out using homogeneous and layered models and final results were also confirmed by Monte Carlo simulations. The depth sensitivity of each technique was investigated and related to the probed region of the cerebral tissue. This work, based on different validated instruments, is a contribution to fill the existing gap between the present knowledge and the actual in-vivo values of the head optical properties.

Keywords: (170.3660) Light propagation in tissues; (170.5280) Photon migration; (170.6935) Tissue characterization; (300.0300) Spectroscopy.

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Figures

Fig. 1
Fig. 1
Experimental setups: a) Continuous-wave camera-based system (CW-camera), b) Time-resolved broadband spectroscopy system (TR-spectr), c) Discrete wavelength time-resolved spectroscopy system (TR-discr), d) Single wavelength time-resolved system (TR-single).
Fig. 2
Fig. 2
CW-camera system: retrieved absorption (a) and reduced scattering spectra (b) for 9 volunteers.
Fig. 3
Fig. 3
TR-spectr system: retrieved absorption (a) and reduced scattering spectra (b) for 9 volunteers.
Fig. 4
Fig. 4
TR-discr system: retrieved absorption and reduced scattering spectra for 9 volunteers. (a) and (c) represent the absorption for the upper and lower layer, respectively. (b) and (d) represent the reduced scattering for the upper and lower layer, respectively.
Fig. 5
Fig. 5
Median absorption (a) and reduced scattering spectra (b) among 9 subjects. Bars refer to the 25th and 75 percentile limits.
Fig. 6
Fig. 6
CW-homo: case 1 (left column) and case 2 (right column).
Fig. 7
Fig. 7
TR-homo: reflectance at 2 cm interfiber distance. Case 1 (left column) and case 2 (right column).
Fig. 8
Fig. 8
TR-homo: reflectance at 9 cm interfiber distance. Case 1 (left column) and case 2 (right column).
Fig. 9
Fig. 9
TR-2L: case 1 (left column) and case 2 (right column).
Fig. 10
Fig. 10
Schematic of the comparison between measurements and simulations. Colored bubbles represents a possible estimate on the volume probed by the measurements performed using the technique/data analysis in the column header.
See this image and copyright information in PMC

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