Hemolysis in Acute Alcoholic Hepatitis: Zieve's Syndrome
- PMID: 26203455
- PMCID: PMC4508957
- DOI: 10.14309/crj.2015.75
Hemolysis in Acute Alcoholic Hepatitis: Zieve's Syndrome
Abstract
A 45-year-old man presented with acute alcoholic hepatitis, jaundice, and anemia on admission. There was no history of bleeding or any evidence of gastrointestinal blood loss. Lab studies revealed hemolysis as the cause of anemia. The patient was diagnosed with Zieve's syndrome and managed with supportive measures. He recovered well and was discharged to a detoxification unit in a stable condition. Zieve's syndrome has been described in literature, mostly in non-English language case studies, but is largely under-recognized and under-reported. Diagnosis should be made quickly to avoid unnecessary invasive diagnostic interventions.
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References
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- Zieve L. Jaundice, hyperlipemia and hemolytic anemia: A heretofore unrecognized syndrome associated with alcoholic fatty liver and cirrhosis. Annals Intern Med. 1958;48(3):471–96. - PubMed
-
- Melrose WD, Bell PA, Jupe DM, Baikie MJ. Alcohol-associated haemolysis in Zieve's syndrome: A clinical and laboratory study of five cases. Clin Lab Haematol. 1990;12(2):159–67. - PubMed
-
- Kunz F, Stummvoll W. The significance of plasma phospholipids in Zieve syndrome. Blut. 1970;21(4):210–26. - PubMed
-
- Piccini J, Haldar S, Jefferson B. Cases from the Osler Medical Service at Johns Hopkins University: Zieve syndrome. Am J Med. 2003;115(9):729–31. - PubMed
-
- Pilcher CR, Underwood RG, Smith HR. Zieve's syndrome a potential surgical pitfall? J R Army Med Corps. 1996;142(2):84. - PubMed
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