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. 2015 Jul 22;20(7):13281-95.
doi: 10.3390/molecules200713281.

The antioxidant activity and their major antioxidant compounds from Acanthopanax senticosus and A. koreanum

Young-Hyun Kim  1 , Myoung Lae Cho  2 , Dan-Bi Kim  3 , Gi-Hae Shin  4 , Jin-Ha Lee  5 , Jong Seok Lee  6 , Sun-Ok Park  7 , Sang-Jong Lee  8 , Hyun Mu Shin  9 , Ok-Hwan Lee  10
Affiliations

The antioxidant activity and their major antioxidant compounds from Acanthopanax senticosus and A. koreanum

Young-Hyun Kim et al. Molecules. .

Abstract

The antioxidant activity and chlorogenic acid and caffeic acid contents were investigated from different parts of Acanthopanax senticosus and A. koreanum. Antioxidant activity was assessed by various in vitro assays such as DPPH, ABTS, FRAP, reducing power assays and ORAC, and the chlorogenic acid and caffeic acid were validated by HPLC chromatography. Among the various extracts, the fruit extracts of A. senticosus and A. koreanum exhibited strongest antioxidant activities including ABTS, FRAP, reducing power and ORAC, however, strongest DPPH radical scavenging activity was observed from the leaf extract of A. senticosus. In addition, the antioxidant activities of various extracts were correlated with total phenolic and proanthocyanidin contents. The major phenolic contents from various parts of these plants observed that leaf extract of A. senticosus expressed higher levels of chlorogenic acid (14.86 mg/dry weigh g) and caffeic acid (3.09 mg/dry weigh g) than other parts. Therefore, these results suggest that the leaf of A. senticosus may be an excellent natural source for functional foods and pharmaceutical agents, and the validated method was useful for the quality control of A. senticosus.

Keywords: Acanthopanax senticosus; antioxidant activity; caffeic acid; chlorogenic acid; method validation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
DPPH radical scavenging activity (A); ABTS radical scavenging activity (B); FRAP activity (C); Reducing power (D); and ORAC (E) in the different parts of A. senticosus and A. koreanum. Each bar represents the mean ± SD of triplicate determinations, n = 3. Statistical analysis was performed using one-way ANOVA (p < 0.05).
Figure 2
Figure 2
PDA spectrums of caffeic acid and chlorogenic acid (A); and HPLC chromatograms of phenolic compounds (chlorogenic acid, caffeic acid, p-coumaric acid, and ferulic acid) (B) of leaf extract from A. senticosus.
See this image and copyright information in PMC

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