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Review
. 2015 Sep;15(6):fov068.
doi: 10.1093/femsyr/fov068. Epub 2015 Jul 22.

Glucose repression in Saccharomyces cerevisiae

Ömur Kayikci  1 , Jens Nielsen  2
Affiliations
Review

Glucose repression in Saccharomyces cerevisiae

Ömur Kayikci et al. FEMS Yeast Res. 2015 Sep.

Abstract

Glucose is the primary source of energy for the budding yeast Saccharomyces cerevisiae. Although yeast cells can utilize a wide range of carbon sources, presence of glucose suppresses molecular activities involved in the use of alternate carbon sources as well as it represses respiration and gluconeogenesis. This dominant effect of glucose on yeast carbon metabolism is coordinated by several signaling and metabolic interactions that mainly regulate transcriptional activity but are also effective at post-transcriptional and post-translational levels. This review describes effects of glucose repression on yeast carbon metabolism with a focus on roles of the Snf3/Rgt2 glucose-sensing pathway and Snf1 signal transduction in establishment and relief of glucose repression.

Keywords: Snf1 signaling; carbon catabolite repression; carbon metabolism.

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Figures

Graphical Abstract Figure.
Graphical Abstract Figure.
The role of Snf1 signaling in glucose repression and carbon metabolism in Saccharomyces cerevisae.
Figure 1.
Figure 1.
Snf3/ Rgt2 glucose-sensing pathway. Snf3/ Rgt2 glucose-sensing pathway dictates expression levels of hexose transporter (HXT) genes for optimal uptake of glucose at various concentrations.
Figure 2.
Figure 2.
The Snf1 protein kinase is central player in glucose repression pathway. The Snf1 protein kinase regulates glucose repression at transcriptional level by activating or inactivating expression of gluconeogenic genes and genes involved in respiration.
Figure 3.
Figure 3.
The Snf1 protein kinase regulates glucose repression at post-transcriptional and post-translational level. Prominent components of metabolic activity are direct targets of Snf1 kinase activity.
See this image and copyright information in PMC

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