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Comment
. 2015;9(4):280-2.
doi: 10.1080/19336918.2015.1019999. Epub 2015 Jul 24.

Multicellular cuddling in a stem cell niche

Andrés Hidalgo  1 , Jacky G Goetz
Affiliations
Comment

Multicellular cuddling in a stem cell niche

Andrés Hidalgo et al. Cell Adh Migr. 2015.

Abstract

Haematopoietic stem and progenitor cells (HSPCs) can self-renew and differentiate in any blood cell type throughout life and thereby sustain the entire blood system. To do so, HSPCs had been shown to seed, in a multi-step process, intermediate haematopoietic niches before colonizing the adult marrow. While HSPC birth had been thoroughly characterized in the past, both in mammals and in zebrafish, how perivascular niches could host HSPCs and sustain their expansion was poorly understood. In an article published in the last issue of Cell, Tamplin et al. (1) elegantly exploited the many advantages provided by the zebrafish embryo to describe how endothelium remodeling in the perivascular niche, referred to as "cuddling," favors HSPCs colonization and expansion.

Keywords: blood; bone marrow; extravasation; haematopoietic stem cell; vascular niche.

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Figures

Figure 1.
Figure 1.
Endothelial cuddling in the perivascular niche favors stem cell colonization
See this image and copyright information in PMC

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References

    1. Tamplin OJ, et al.. Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche. Cell 2015; 160:241-52; PMID:25594182; http://dx.doi.org/10.1016/j.cell.2014.12.032 - DOI - PMC - PubMed
    1. Kissa K, Herbomel P. Blood stem cells emerge from aortic endothelium by a novel type of cell transition. Nature 2010; 464:112-5; PMID:20154732; http://dx.doi.org/10.1038/nature08761 - DOI - PubMed
    1. Bertrand JY, et al.. Haematopoietic stem cells derive directly from aortic endothelium during development. Nature 2010; 464:108-11; PMID:20154733; http://dx.doi.org/10.1038/nature08738 - DOI - PMC - PubMed
    1. Boisset JC, et al.. In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium. Nature 2010; 464:116-20; PMID:20154729; http://dx.doi.org/10.1038/nature08764 - DOI - PubMed
    1. Traver D, et al.. Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. Nat Immunol 2003; 4:1238-46; PMID:14608381; http://dx.doi.org/10.1038/ni1007 - DOI - PubMed

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