Association of the Laennec staging system with degree of cirrhosis, clinical stage and liver function

Abstract

Objectives: The aim of this study was to investigate the association of the Laennec staging system with degree of cirrhosis, clinical stage and liver function.

Methods: Liver biopsy was performed for 30 patients with hepatitis B cirrhosis to test the content of hydroxyproline in hepatic tissue, judge the degree of cirrhosis and determine the Laennec staging system. The association of the Laennec staging system with the degree of cirrhosis, clinical stage and liver function was compared.

Results: The Laennec staging system had a close association with clinical stage, model for end-stage liver disease score and degree of cirrhosis (r = 0.58, p < 0.01; r = 0.60, p < 0.01; r = 0.53, p < 0.01).

Conclusions: The Laennec histological grading system can to some extent reflect the degree of cirrhosis, clinical stage and liver function, and is expected to predict the incidence of patient complications in a useful way.

Keywords: Cirrhosis; Clinical stage; Collagen; Pathological grading.