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Review
. 2015 Aug;35(3):403-11.
doi: 10.1016/j.iac.2015.04.002. Epub 2015 Jun 17.

Spectrum of Eosinophilic End-Organ Manifestations

Praveen Akuthota  1 , Peter F Weller  2
Affiliations
Review

Spectrum of Eosinophilic End-Organ Manifestations

Praveen Akuthota et al. Immunol Allergy Clin North Am. 2015 Aug.

Abstract

Eosinophil-associated disorders can affect practically all tissues and organs in the body, either individually or in combination. This article provides an overview of end-organ manifestations of eosinophilia and discusses selected organ systems, including the upper and lower respiratory, cardiovascular, gastrointestinal, nervous, dermatologic, and renal systems. Mechanisms by which eosinophilia leads to end-organ damage are also considered.

Keywords: Churg-Strauss syndrome; Eosinophilic esophagitis; Eosinophilic granulomatous vasculitis; Eosinophils immunology; Eosinophils pathology; Humans; Hypereosinophilic syndrome; Pulmonary eosinophilia.

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Conflict of interest statement

The authors have no financial disclosures or conflicts of interest relevant to the content of this article.

References

    1. Akuthota P, Wang HB, Spencer LA, et al. Immunoregulatory roles of eosinophils: a new look at a familiar cell. Clin Exp Allergy. 2008;38(8):1254–1263. - PMC - PubMed
    1. Shamri R, Xenakis JJ, Spencer LA. Eosinophils in innate immunity: an evolving story. Cell Tissue Res. 2011;343(1):57–83. - PMC - PubMed
    1. Akuthota P, Weller PF. Eosinophilic pneumonias. Clin Microbiol Rev. 2012;25(4):649–660. - PMC - PubMed
    1. DeBrosse CW, Rothenberg ME. Allergy and eosinophil-associated gastrointestinal disorders (EGID) Curr Opin Immunol. 2008;20(6):703–708. - PMC - PubMed
    1. Ogbogu PU, Bochner BS, Butterfield JH, et al. Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy. J Allergy Clin Immunol. 2009;124(6):1319–1325. e1313. - PMC - PubMed

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