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Comparative Study
. 2015 Oct;100(4):1211-6.
doi: 10.1016/j.athoracsur.2015.04.114. Epub 2015 Jul 23.

Survival in Adult Lung Transplant Recipients Receiving Pediatric Versus Adult Donor Allografts

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Comparative Study

Survival in Adult Lung Transplant Recipients Receiving Pediatric Versus Adult Donor Allografts

Don Hayes Jr et al. Ann Thorac Surg. 2015 Oct.

Abstract

Background: Recent evidence showed that pediatric donor lungs increased rates of allograft failure in adult lung transplant recipients; however, the influence on survival is unclear.

Methods: The United Network for Organ Sharing (UNOS) database was queried from 2005 to 2013 for adult lung transplant recipients (≥18 years) to assess survival differences among donor age categories (<18 years, 18 to 29 years, 30 to 59 years, ≥60 years).

Results: Of 12,297 adult lung transplants, 12,209 were used for univariate Cox models and Kaplan-Meier (KM) analysis and 11,602 for multivariate Cox models. A total of 1,187 adult recipients received pediatric donor lungs compared with 11,110 receiving adult donor organs. Univariate and multivariate Cox models found no difference in survival between donor ages 0 to 17 and donor ages 18 to 29, whereas donor ages 60 and older were significantly associated with increased mortality hazard, relative to the modal category of donor ages 30 to 59 (adjusted hazard ratio = 1.381; 95% confidence interval = 1.188% to 1.606%; p < 0.001). Interactions between recipient and donor age range found that the oldest donor age range was negatively associated with survival among middle-aged (30 to 59) and older (≥60) lung transplant recipients.

Conclusions: Pediatric donor lung allografts were not negatively associated with survival in adult lung transplant recipients; however, the oldest donor age range was associated with increased mortality hazard for adult lung transplant recipients.

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Comment in

  • Invited Commentary.
    Pal JD, Makey IA. Pal JD, et al. Ann Thorac Surg. 2015 Oct;100(4):1216-7. doi: 10.1016/j.athoracsur.2015.05.028. Ann Thorac Surg. 2015. PMID: 26434430 No abstract available.

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