Potential Competing Interests: Dr Antman reports he is a member of the Data Monitoring Committee, and has received grants, personal fees, nonfinancial support, and other as Dean of Boston University School of Medicine, outside the submitted work; he also serves as a trustee of the Faculty Practice Plan and of the principal teaching hospital. Dr Baker reports personal fees from Morphotek, Immune Design, Marathon Pharmaceutical, INC Research, and Cyt Rx, outside the submitted work. Dr Bennett reports personal fees from Celgene Corp, Amgen, Novartis, and Glaxo, outside the submitted work. Dr Bhojwani reports participation on the Advisory Board at Amgen and Incyte Pharmaceuticals. Dr Broxmeyer reports receiving an honorarium from Corduse, a Cord Blood Banking Company, outside the submitted work. Dr Chabner reports personal fees from Epizyme, Merrimack, PharmaMar, Sanofi Aventis, Eli Lilly, Celgene, Biomarin, Clovis, Gilead, Seattle Genetics, and Biogen, outside the submitted work. Dr Chesson worked as consultant for Astellas, AstraZeneca, Celgene, Genetech, Gilead, Pfizer, Pharmacyclics, Amgen, Spectrum, Seattle Genetics; his institution received research support from AbbVie, Acerta, Celgene, Genentech, Gilead, Medimmune, Pharmacyclics, Teva, and Seattle Genetics. Dr Colon-Otero reports grants from Novartis, during the conduct of the study. Dr Daley reports a consulting or scientific advisory relationship and holder of equity or options with the following entities: MPM Capital, Epizyme, Verastem, Solasia, KK, True North, Ocata, Raze; in addition, Dr. Daley holds patents broadly related to cancer biology (See http://www.faqs.org/patents/inventor/george-q-daley-weston-US-1/). Dr DeAngelo reports personal fees from Novartis, Ariad, BMS, Pfizer, Astra-Zeneca, Boehringer Ingelheim, Amgen, and Incyte, outside the submitted work. Dr Einhorn served on the scientific advisory board for Celgene and Ziopharm and owns stock at Amgen and Biogenetics. Dr Erba reports personal fees from Novartis, Incyte, Celgene, Sunesis, Pfizer, and Ariad; grants from Celator, grants and personal fees from Seattle Genetics, grants and personal fees from Amgen, and grants from Millennium/Takeda and Astellas, outside the submitted work. Dr Hortobagyi reports personal fees from Bayer HealthCare Pharmaceuticals, Metastat, Peregrine Pharmaceuticals, Inc, Celgene Corp, Pfizer Inc, Society for Translational Oncology, Antigen Express, Galena Biopharma, Genentech, Inc, Amgen Inc, Rockpointe, AstraZeneca Pharmaceuticals, and grants and personal fees from Novartis Pharmaceuticals Corp, outside the submitted work. Dr Issa reports grants from Astex and AACR/Stand Up To Cancer, during the conduct of the study; grants and personal fees from Astex, and personal fees from Janssen Teva, and Boehringer, outside the submitted work. Dr Johnson reports personal fees from Novartis, Merck, AstraZeneca, Clovis Oncology, Chugai Pharmacuticals, Transgene, Genentech, Otsuka, and Eli Lilly, outside the submitted work; in addition, Dr Johnson has a patent on EGFR Mutation Testing with royalties paid and is a stockholder of KEW Group. Dr. Lonial reports personal fees from Millennium, Celgene, Novartis, BMS, Onyx, and Janssen, outside the submitted work. Dr Mendelsohn reports personal fees and other from Merrimack Pharmaceuticals, outside the submitted work; in addition, Dr. Mendelsohn has a UCSD patent on Erbitux with royalties paid. Dr Meropol reports personal fees from biomotiv, outside the submitted work; in addition, Dr. Meropol has a US Patent Office 20020031515 “Methods of therapy for cancers characterized by over expression of the HER2 receptor protein” (expires May 14, 2021) issued and is an elected board member of the American Society of Clinical Oncology and Eastern Cooperative Oncology Group Research and Education Foundation. Dr Messinger reports personal fees from Jazz Pharmaceuticals and Sigma Tau, outside the submitted work, in both cases honorarium for one-time advisory board participation. Dr Press reports personal fees from Algeta and Roche/Genentech, and other from Emergent Biosolutions, PhaseRx, and Roche/Genentech, outside the submitted work. Dr Rugo reports other from Novartis, outside the submitted work. Dr Sekeres reports personal fees from Celgene, Boehringer-Ingelheim, Amgen, MEI, and Seattle Genetics, outside the submitted work. Dr Steensma reports personal fees from Celgene, Novartis, Genoptix, Amgen, Onconova, and from MEI Pharma, outside the submitted work. Dr Stewart received compensation from NGCN and George Washington University for speaking. Dr Stock reports personal fees from Amgen, Gilead, ADC Pharmaceutical, Sigma Tau, Up to Date, and American Society of Hematology, outside the submitted work. Dr Stone reports personal fees from Agios, Amgen, Abbvie, Arog, BMS, Celator, Celgene, Pfizer, Roche/Genetech, Karyopharm, and Merck, outside the submitted work. Dr Van Etten reports personal fees and other from Deciphera Pharmaceuticals, Sunesis Pharmaceuticals, Karyopharm Pharmaceuticals, and grants from Verastem, outside the submitted work. Dr Zelenet reports fees from Adaptive Biotechnologies Corp, Alissa Pharma, Amgen, Boehringer Ingelheim, Celgene, Clinical Care Options, Dr. Reddy’s Laboratories, Genentech/Roche, Gilead, Hospira, Novartis, Onyx Pharmaceuticals, Pfizer, Sandoz, and Sanofi Aventis, outside the submitted work. The remaining authors report no competing interests.