Biotechnological approaches to enhance salidroside, rosin and its derivatives production in selected Rhodiola spp. in vitro cultures

Abstract

Rhodiola (Crassulaceae) an arctic-alpine plant, is extensively used in traditional folk medicine in Asian and European countries. A number of investigations have demonstrated that Rhodiola preparations exhibit adaptogenic, neuroprotective, anti-tumour, cardioprotective, and anti-depressant effects. The main compounds responsible for these activities are believed to be salidroside, rosin and its derivatives which became the target of biotechnological investigations. This review summarizes the results of the diverse biotechnological approaches undertaken to enhance the production of salidroside, rosin and its derivatives in callus, cell suspension and organ in vitro cultures of selected Rhodiola species.

Keywords: Biotransformation; In vitro cultures; Rhodiola spp.; Rosin derivatives; Salidroside.

Fig. 1

Biosynthetic pathway of salidroside (Ma et al. 2008). Phe l-phenylalanine, Tyr l-tyrosine, PAL phenylalanine ammonia-lyase, TyrDC tyrosine decarboxylase, 4-HPAA 4-hydroxyphenylacetaldehyde

Fig. 2

Biosynthetic pathway of rosin, rosavin and rosarin (György 2006)