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Review
. 2015 Jul 23;13(8):4594-616.
doi: 10.3390/md13084594.

A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi

Yan-Ting Wang  1 , Ya-Rong Xue  2 , Chang-Hong Liu  3
Affiliations
Review

A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi

Yan-Ting Wang et al. Mar Drugs. .

Abstract

Deep-sea fungi, the fungi that inhabit the sea and the sediment at depths of over 1000 m below the surface, have become an important source of industrial, agricultural, and nutraceutical compounds based on their diversities in both structure and function. Since the first study of deep-sea fungi in the Atlantic Ocean at a depth of 4450 m was conducted approximately 50 years ago, hundreds of isolates of deep-sea fungi have been reported based on culture-dependent methods. To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature. These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities. In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development.

Keywords: anticancer; antifungal; antimicrobial; antiviral; bioactive compounds; deep-sea fungi.

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Figures

Figure 1
Figure 1
Chemical structures of compounds 1–16.
Figure 2
Figure 2
Chemical structures of compounds 17–30.
Figure 3
Figure 3
Chemical structures of compounds 31–36.
Figure 4
Figure 4
Chemical structures of compounds 37–40.
Figure 5
Figure 5
Chemical structures of compounds 41–47.
Figure 6
Figure 6
Chemical structures of compounds 48–51.
Figure 7
Figure 7
Chemical structures of compounds 52–54.
Figure 8
Figure 8
Chemical structures of compounds 55–61.
Figure 9
Figure 9
Chemical structures of compounds 62–72.
Figure 10
Figure 10
Chemical structures of compounds 73–75.
Figure 11
Figure 11
Chemical structures of compounds 76–81.
Figure 12
Figure 12
Chemical structures of compounds 82–84.
Figure 13
Figure 13
Chemical structures of compounds 85–90.
Figure 14
Figure 14
Chemical structures of compounds 91–94.
Figure 15
Figure 15
Chemical structures of compounds 95–100.
Figure 16
Figure 16
Chemical structures of compounds 101–103.
Figure 17
Figure 17
Chemical structures of compounds 104–113.
Figure 18
Figure 18
Chemical structures of compounds 114–119.
Figure 19
Figure 19
Chemical structures of compounds 120 and 121.
Figure 20
Figure 20
Chemical structures of compounds 122–127.
Figure 21
Figure 21
Chemical structures of compounds 128–131.
Figure 22
Figure 22
Chemical structures of compounds 132–138.
Figure 23
Figure 23
Chemical structures of compounds 139–148.
Figure 24
Figure 24
Chemical structures of compounds 149–163.
Figure 25
Figure 25
Chemical structure of compound 164.
Figure 26
Figure 26
Chemical structure of compound 165.
Figure 27
Figure 27
Chemical structures of compounds 166–170.
Figure 28
Figure 28
Chemical structure of compound 171.
Figure 29
Figure 29
Chemical structures of compounds 172–177.
Figure 30
Figure 30
Chemical structure of compound 178.
Figure 31
Figure 31
Chemical structures of compounds 179–180.
Figure 32
Figure 32
Chemical structures of compounds 181 and 182.
See this image and copyright information in PMC

References

    1. Park Y.C., Gunasekera S.P., Lopez J.V., McCarthy P.J., Wright A.E. Metabolites from the marine-derived fungus Chromocleista sp. isolated from a deep-water sediment sample collected in the Gulf of Mexico. J. Nat. Prod. 2006;69:580–584. doi: 10.1021/np058113p. - DOI - PubMed
    1. Swathi J., Narendra K., Sowjanya K.M., Satya A.K. Evaluation of biologically active molecules isolated from obligate marine fungi. Mintage J. Pharm. Med. Sci. 2013;2:45–47.
    1. Mahé S., Rédou V., Calvez T.L., Vandenkoornhuyse P., Burgaud G. Fungi in deep-sea environments and metagenomics. In: Martin F., editor. The Ecological Genomics of Fungi. John Wiley & Sons, Inc.; Hoboken, NJ, USA: 2013. pp. 325–354.
    1. Hua W., Chen X., Cui X. Preliminary study of deep-sea fungi and their bioactive secondary metabolites; Proceedings of the Eleventh National Symposia of Chinese Medicine and Natural Products; Shenyang, China. 19–20 October 2011; p. 46. (In Chinese)
    1. Yu L. Master’s Thesis. The Third Institute of Oceanography, State Oceanic Administration; Xiamen: 2011. Identification and biological activity evaluation of three microbial strains isolated from deep-sea sediments. (In Chinese)

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