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Review
. 2015 May-Jun;20(3):673-9.

The role of CDCP1 (CUB domain-containing protein 1) and ADAM12 (a disintegrin and metalloproteinase 12) in ovarian cancer

Catalin Vlad  1 , Paul Kubelac, Andrea Onisim, Alexandru Irimie, Patriciu Achimas-Cadariu
Affiliations
  • PMID: 26214617
Free article
Review

The role of CDCP1 (CUB domain-containing protein 1) and ADAM12 (a disintegrin and metalloproteinase 12) in ovarian cancer

Catalin Vlad et al. J BUON. 2015 May-Jun.
Free article

Abstract

Ovarian cancer (OC) is the second most common gynecological cancer and the deadliest in industrialized countries, with poor outcomes that indicate an urgent need to provide a greater insight into the molecular mechanisms underlying OC. Insights into the complex tumor microenviroment show that besides tumor islets, OC biomarkers can derive from newly formed blood vessels that have endothelial cells with a different molecular signature in comparison with their normal counterparts. In this view, recent research has been able to highlight promising candidates such as CDCP1 and ADAM12. Our present review summarises their implications in cancer progression with a focus on OC.

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