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. 2015 Sep;25(5):1331-7.
doi: 10.1007/s10895-015-1622-1. Epub 2015 Jul 28.

A New Schiff Base Chemodosimeter for Fluorescent Imaging of Ferric Ions in Living Cells

Yan-Zi Chen  1 , Yeshwant Ramchandra Bhorge  1 , Albert J Pape  1 , Rupesh D Divate  1 , Yun-Chin Chung  1 , Yao-Pin Yen  2
Affiliations

A New Schiff Base Chemodosimeter for Fluorescent Imaging of Ferric Ions in Living Cells

Yan-Zi Chen et al. J Fluoresc. 2015 Sep.

Abstract

A new and efficient chemodosimeter for ferric ions has been developed. The visual and fluorescent behaviors of the compound toward various metal ions were investigated: ferric ions are distinguished from other cations by selective color change and unusual fluorescence enhancement in mixed aqueous solution. Fluorescence microscopy experiments showed that this receptor is effective for detection of Fe(3+) in vitro, developing a good image of the biological organelles. The sensing mechanism is shown to involve a hydrolysis process.

Keywords: Cell imaging; Chemodosimeter; Ferric ion detection; Fluorescence microscopy; Schiff base.

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