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Multicenter Study
. 2015 Sep 30;229(1-2):589-92.
doi: 10.1016/j.psychres.2015.07.046. Epub 2015 Jul 21.

An exploratory association study of the influence of noradrenergic genes and childhood trauma in Borderline Personality Disorder

Ana Martín-Blanco  1 , Marc Ferrer  2 , Joaquim Soler  1 , Maria Jesús Arranz  3 , Daniel Vega  4 , Joana Bauzà  1 , Natalia Calvo  2 , Matilde Elices  1 , Cristina Sanchez-Mora  5 , Iris García-Martinez  5 , Juliana Salazar  6 , Marta Ribases  5 , Cristina Carmona  1 , Mónica Prat  2 , Juan C Pascual  7
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Multicenter Study

An exploratory association study of the influence of noradrenergic genes and childhood trauma in Borderline Personality Disorder

Ana Martín-Blanco et al. Psychiatry Res. .

Abstract

This study investigated the possible association of 40 polymorphisms within 4 noradrenergic genes with BPD risk and the modulating effect of childhood trauma on these associations in 481 BPD subjects and 442 controls. COMT rs5993882, DBH rs77905 and SLC6A2 rs1814270 showed associations with BPD, which were modulated by childhood trauma. However, none of these findings survived Bonferroni correction. Further investigation is needed to clarify the involvement of these genes in BPD pathogenesis.

Keywords: Borderline Personality Disorder; Childhood trauma; Noradrenergic system.

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