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Comment
. 2015 Aug;146(2):123-7.
doi: 10.1085/jgp.201511469.

What keeps Kv channels small? The molecular physiology of modesty

Jon T Sack  1 , Drew C Tilley  2
Affiliations
Comment

What keeps Kv channels small? The molecular physiology of modesty

Jon T Sack et al. J Gen Physiol. 2015 Aug.
No abstract available

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Figures

Figure 1.
Figure 1.
Sequence alignment of S6 regions of K+ channels discussed herein. Residues that increase unitary conductance when mutated to aspartate are colored red. Acidic residues that decrease unitary conductance when neutralized are gray.
Figure 2.
Figure 2.
Illustration of K+ channel regions contributing to electrical resistance. (Far left) Vertical slice through the axis of symmetry of the Kv1.2 pore (Protein Data Bank accession no. 2R9R), with surface rendering of the inner cavity. Residues mutated to aspartate by Díaz-Franulic et al. (2015) are colored red; K+ is colored violet. The relative electrical resistance of permeation path segments in Shaker wild-type, Shaker P475D, and BK channels is schematized from left to right. Coloring crudely reflects the resistances reported by Díaz-Franulic et al.
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References

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