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. 2014 Jun;30(2):49-55.
doi: 10.5758/vsi.2014.30.2.49. Epub 2014 Jun 30.

Occurrence and Prognosis of Symptomatic Venous Thromboembolism in Colorectal Cancer Surgery Patients

Dae Sik Kim  1 , Keun-Myoung Park  1 , Yong Sung Won  1 , Jang Yong Kim  1 , Jin Kwon Lee  1 , Jun Gi Kim  1 , Seong Taek Oh  1 , Sang Seol Jung  1 , Won Kyung Kang  1
Affiliations

Occurrence and Prognosis of Symptomatic Venous Thromboembolism in Colorectal Cancer Surgery Patients

Dae Sik Kim et al. Vasc Specialist Int. 2014 Jun.

Abstract

Purpose: Colorectal cancer (CRC) has a high risk for postoperative thromboembolic complications such as venous thromboembolism (VTE) compared to other surgical diseases, but the relationship between VTE and CRC in Asian patients remains poorly understood. The present study examined the incidence of symptomatic VTE in Korean patients who underwent surgery for CRC. We also identified risk factors, incidence and survival rate for VTE in these patients.

Materials and methods: The patients were identified from the CRC database treated from January 2011 to December 2012 in a single institution. These patients were classified into VTE and non-VTE groups, their demographic features were compared, and the factors which had significant effects on VTE and mortality between the two groups were analyzed.

Results: We analyzed retrospectively a total of 840 patients and the incidence of VTE was 3.7% (31 patients) during the follow-up period (mean, 17.2 months). Histologic subtype (mucinous adenocarcinoma) and previous history of VTE affected the incidence of VTE on multivariate analysis. There was a statistically significant difference in survival rate between the VTE and non-VTE group, but VTE wasn't the factor affecting survival rate on multivariate analysis. Comparing differences in survival rate for each pathologic stage, there was only a significant difference in stage II patients.

Conclusion: Among CRC patients after surgery, the incidence of VTE was approximately 3% within 1 year and development of VTE wasn't a significant risk factor for death in our study but these findings are not conclusive due to our small sample size.

Keywords: Colorectal cancer; Survival rate; Venous thromboembolism.

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Figures

Fig. 1.
Fig. 1.
Incidence of venous thromboembolism after colorectal cancer surgery.
Fig. 2.
Fig. 2.
Comparison of survival rate between venous thromboembolism (VTE) group and non-VTE group.
Fig. 3.
Fig. 3.
Comparison of survival rate between venous thromboembolism (VTE) group and non-VTE group according to the stage. (A) Stage I, (B) stage II, (C) stage III, (D) stage IV.
See this image and copyright information in PMC

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