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Comment

. 2015;9(5):227-9.

doi: 10.1080/19336950.2015.1075784. Epub 2015 Jul 28.

Zinc controls RyR2 activity during excitation-contraction coupling

Alan J Stewart¹, Samantha J Pitt¹

Affiliations

PMID: 26218467
PMCID: PMC4826112
DOI: 10.1080/19336950.2015.1075784

Comment

Zinc controls RyR2 activity during excitation-contraction coupling

Alan J Stewart et al. Channels (Austin). 2015.

. 2015;9(5):227-9.

doi: 10.1080/19336950.2015.1075784. Epub 2015 Jul 28.

Authors

Alan J Stewart¹, Samantha J Pitt¹

Affiliation

¹ a School of Medicine, University of St Andrews ; St Andrews , UK.

PMID: 26218467
PMCID: PMC4826112
DOI: 10.1080/19336950.2015.1075784

No abstract available

PubMed Disclaimer

Figures

Figure 1. — Figure 1.
A model to show how zinc may regulate RyR2-mediated sarcoplasmic reticulum calcium release. Physiological conditions: During the resting phase of the cardiac cycle RyR2 is closed as the cytosolic [Ca²⁺] is sub-activating (100 nM). The normal trigger for RyR2 activation during systole is a transient rise in [Ca²⁺] (≥ 1 µM). Zn²⁺-dyshomeostasis: If the intracellular [Zn²⁺] rises >1 nM, the dependency on Ca²⁺ for RyR2 openings is removed and Zn²⁺ becomes the activating ligand. This leads to abnormally active channels.

See this image and copyright information in PMC

Comment on

Intracellular Zinc Modulates Cardiac Ryanodine Receptor-mediated Calcium Release.
Woodier J, Rainbow RD, Stewart AJ, Pitt SJ. Woodier J, et al. J Biol Chem. 2015 Jul 10;290(28):17599-610. doi: 10.1074/jbc.M115.661280. Epub 2015 Jun 3. J Biol Chem. 2015. PMID: 26041778 Free PMC article.

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