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Comment
. 2015 Aug;47(8):853-5.
doi: 10.1038/ng.3364.

Running spell-check to identify regulatory variants

Martin Kircher  1 , Jay Shendure  1
Affiliations
Comment

Running spell-check to identify regulatory variants

Martin Kircher et al. Nat Genet. 2015 Aug.

Abstract

A major challenge in human genetics is pinpointing which non-coding genetic variants affect gene expression and disease risk. A new study in this issue describes a broadly applicable approach for this task that explicitly models cell type-specific regulatory motifs and generates variant effect predictions that are more accurate and interpretable than those of alternative tools.

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References

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