Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015:2015:531740.
doi: 10.1155/2015/531740. Epub 2015 Jun 28.

MicroRNA-143/-145 in Cardiovascular Diseases

Wang Zhao  1 , Shui-Ping Zhao  1 , Yu-Hong Zhao  1
Affiliations
Review

MicroRNA-143/-145 in Cardiovascular Diseases

Wang Zhao et al. Biomed Res Int. 2015.

Abstract

MicroRNAs (miRNAs) play an essential role in the onset and development of many cardiovascular diseases. Increasing evidence shows that miRNAs can be used as potential diagnostic biomarkers for cardiovascular diseases, and miRNA-based therapy may be a promising therapy for the treatment of cardiovascular diseases. The microRNA-143/-145 (miR-143/-145) cluster is essential for differentiation of vascular smooth muscle cells (VSMCs) and determines VSMC phenotypic switching. In this review, we summarize the recent progress in knowledge concerning the function of miR-143/-145 in the cardiovascular system and their role in cardiovascular diseases. We discuss the potential role of miR-143/-145 as valuable biomarkers for cardiovascular diseases and explore the potential strategy of targeting miR-143 and miR-145.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Roles of miR-143/-145 in the regulation of vascular smooth muscle cell differentiation and proliferation (adapted from Cordes et al. [31]). Expressions of miR-143/-145 are positively regulated by SRF with the functions to repress several factors, including KLF4 and Elk-1, which are reported to be involved in the regulation of smooth muscle cell proliferation, leading to promotion of smooth muscle cell differentiation and inhibition of proliferation. SRF: serum response factor; Myocd: myocardin; KLF4: Kruppel-like factor 4; Elk-1: Ets-like gene 1.
See this image and copyright information in PMC

References

    1. Bartel D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116(2):281–297. doi: 10.1016/s0092-8674(04)00045-5. - DOI - PubMed
    1. Bentwich I., Avniel A., Karov Y., et al. Identification of hundreds of conserved and nonconserved human microRNAs. Nature Genetics. 2005;37(7):766–770. doi: 10.1038/ng1590. - DOI - PubMed
    1. Friedman R. C., Farh K. K.-H., Burge C. B., Bartel D. P. Most mammalian mRNAs are conserved targets of microRNAs. Genome Research. 2009;19(1):92–105. doi: 10.1101/gr.082701.108. - DOI - PMC - PubMed
    1. Small E. M., Olson E. N. Pervasive roles of microRNAs in cardiovascular biology. Nature. 2011;469(7330):336–342. doi: 10.1038/nature09783. - DOI - PMC - PubMed
    1. He L., Hannon G. J. MicroRNAs: small RNAs with a big role in gene regulation. Nature Reviews Genetics. 2004;5(7):522–531. doi: 10.1038/nrg1379. - DOI - PubMed

LinkOut - more resources