Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Sep 9;27(34):5063-9.
doi: 10.1002/adma.201502201. Epub 2015 Jul 29.

Engineering Melanin Nanoparticles as an Efficient Drug-Delivery System for Imaging-Guided Chemotherapy

Ruiping Zhang  1   2 , Quli Fan  3 , Min Yang  2   4 , Kai Cheng  2 , Xiaomei Lu  3 , Lei Zhang  3 , Wei Huang  3 , Zhen Cheng  2
Affiliations

Engineering Melanin Nanoparticles as an Efficient Drug-Delivery System for Imaging-Guided Chemotherapy

Ruiping Zhang et al. Adv Mater. .

Abstract

In order to promote imaging-guided chemotherapy for preclinical and clinical applications, endogenous nanosystems with both contrast and drug-delivery properties are highly desired. Here, the simple use of melanin is first reported, and this biopolymer with good biocompatibility and biodegradability, binding ability to drugs and ions, and intrinsic photoacoustic properties, can serve as an efficient endogenous nanosystem for imaging-guided tumor chemotherapy in living mice.

Keywords: drug delivery; melanin nanoparticles; photoacoustic imaging; positron emission tomography (PET); sorafenib.

PubMed Disclaimer

Publication types