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Comment
. 2015;14(18):2863-4.
doi: 10.1080/15384101.2015.1076300.

DNA methylation plasticity contributes to the natural history of metastasis

Miguel Vizoso  1 , Manel Esteller  1   2   3
Affiliations
Comment

DNA methylation plasticity contributes to the natural history of metastasis

Miguel Vizoso et al. Cell Cycle. 2015.
No abstract available

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Figures

Figure 1.
Figure 1.
Epigenetic plasticity throughout the genome drives tumor initiation, promotion and progression. Panel illustrating tumorigenesis, from normal cells expressing common cell adhesion molecules and miRNA profiles to proliferative and invasive cells with an uncountable number of epigenetic disruptions. The picture highlights the importance of epigenetic plasticity to the invasive capacity of tumor cells and the EMT/MET processes in tumorigenesis. Head arrows indicates upregulation or downregulation in gene expression; green denotes hypomethylation events while red hypermethylation events.
See this image and copyright information in PMC

Comment on

  • Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR.
    Vizoso M, Ferreira HJ, Lopez-Serra P, Carmona FJ, Martínez-Cardús A, Girotti MR, Villanueva A, Guil S, Moutinho C, Liz J, Portela A, Heyn H, Moran S, Vidal A, Martinez-Iniesta M, Manzano JL, Fernandez-Figueras MT, Elez E, Muñoz-Couselo E, Botella-Estrada R, Berrocal A, Pontén F, Oord Jv, Gallagher WM, Frederick DT, Flaherty KT, McDermott U, Lorigan P, Marais R, Esteller M. Vizoso M, et al. Nat Med. 2015 Jul;21(7):741-50. doi: 10.1038/nm.3863. Epub 2015 Jun 1. Nat Med. 2015. PMID: 26030178 Free PMC article.

References

    1. Timp W, Feinberg AP. Nat Rev Cancer 2013; 13:497-510; PMID:23760024; http://dx.doi.org/10.1038/nrc3486 - DOI - PMC - PubMed
    1. Lujambio A, et al. Proc Natl Acad Sci U S A 2008; 105:13556-61; PMID:18768788; http://dx.doi.org/10.1073/pnas.0803055105 - DOI - PMC - PubMed
    1. Carmona FJ, et al. J Pathol 2012; 228:230-40; PMID:22374749; http://dx.doi.org/10.1002/path.4011 - DOI - PMC - PubMed
    1. Fang F, et al. Sci Transl Med 2011; 3:75ra25; PMID:21430268; http://dx.doi.org/10.1126/scitranslmed.3001875 - DOI - PMC - PubMed
    1. Vizoso M, et al. Nat Med 2015; 21(7):741-50; PMID:26030178; http://dx.doi.org/10.1038/nm.3863 - DOI - PMC - PubMed

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