Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2015 Sep 2;34(17):2217-8.
doi: 10.15252/embj.201592519. Epub 2015 Jul 28.

Scissors for autolysosome tubules

Yang Chen  1 , Li Yu  1
Affiliations
Comment

Scissors for autolysosome tubules

Yang Chen et al. EMBO J. .

Abstract

Autophagic lysosome reformation (ALR) is a cellular process in which lysosomes are reformed through scission of proto-lysosomes from tubular structures extruded from autolysosomes. Despite recent progress, the molecular mechanism of ALR is far from clear. A paper in this issue of The EMBO Journal has identified lysosome-localized PI(3)P, which is generated by the VPS34–UVRAG complex in an mTOR-dependent manner, as an important regulator of autolysosome tubule scission (Munson et al, 2015).

PubMed Disclaimer

Figures

Figure 1
Figure 1
Summary of the regulatory pathway of ALR tubule scission
See this image and copyright information in PMC

Comment on

References

    1. Chen Y, Yu L. Autophagic lysosome reformation. Exp Cell Res. 2013;319:142–146. - PubMed
    1. Munson MJ, Allen GF, Toth R, Campbell DG, Lucocq JM, Ganley IG. mTOR activates the VPS34–UVRAG complex to regulate autolysosomal tubulation and cell survival. EMBO J. 2015;34:2272–2290. - PMC - PubMed
    1. Rong Y, Liu M, Ma L, Du W, Zhang H, Tian Y, Cao Z, Li Y, Ren H, Zhang C, Li L, Chen S, Xi J, Yu L. Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation. Nat Cell Biol. 2012;14:924–934. - PubMed
    1. Rong Y, McPhee CK, Deng S, Huang L, Chen L, Liu M, Tracy K, Baehrecke EH, Yu L, Lenardo MJ. Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation. Proc Natl Acad Sci USA. 2011;108:7826–7831. - PMC - PubMed
    1. Schulze RJ, Weller SG, Schroeder B, Krueger EW, Chi S, Casey CA, McNiven MA. Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes. J Cell Biol. 2013;203:315–326. - PMC - PubMed

MeSH terms

Substances