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. 2015 May;36(2):75-82.

Adventures with Creatinine and eGFR - A National, International and Personal Story - AACB Roman Lecture 2014

Graham R D Jones  1
Affiliations

Adventures with Creatinine and eGFR - A National, International and Personal Story - AACB Roman Lecture 2014

Graham R D Jones. Clin Biochem Rev. 2015 May.

Abstract

In Australia and New Zealand today there is a commonality in all laboratories in many areas of testing related to Chronic Kidney Disease (CKD). These include creatinine assay standardisation, estimated Glomerular Filtration Rate (eGFR) reporting and the use of common units for serum creatinine and eGFR. This is supported by a single definition for diagnosis and staging of CKD, agreed indications for who and how to test together with detailed advice on test interpretation and patient management provided by our nephrology colleagues. These outcomes are the product of a decade of effort within Australia and New Zealand with collaboration between clinical disciplines and amongst laboratories. These local activities have been based on and supported by international actions in assay standardisation, eGFR formula development, understanding of clinical outcomes and guideline development. It is my belief that the local implementation of the current laboratory-based CKD testing processes is an outstanding example of good laboratory practice. This paper outlines the local and international activities and provides a view of my personal adventures with creatinine and eGFR.

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Figures

Figure 1.
Figure 1.
Two dimensional “Heat Map” for CKD classification. Reproduced with permission from KDIGO. For colour version see reference .
Figure 2.
Figure 2.
Between-method variation in serum creatinine assays in Australia. A, In 2006 and B, from 2011.
See this image and copyright information in PMC

References

    1. The W. Roman Travelling Lectureship. http://www.aacb.asn.au/professionaldevelopment/roman-lectures (Accessed 1 March 2014).
    1. Johnson DW, Jones GR, Mathew TH, Ludlow MJ, Doogue MP, Jose MD, et al. Australasian Creatinine Consensus Working Group Chronic kidney disease and automatic reporting of estimated glomerular filtration rate: new developments and revised recommendations. Med J Aust. 2012;197:224–5. - PubMed
    1. Johnson DW, Jones GR, Mathew TH, Ludlow MJ, Chadban SJ, Usherwood T, et al. Australasian Proteinuria Consensus Working Group Chronic kidney disease and measurement of albuminuria or proteinuria: a position statement. Med J Aust. 2012;197:224–5. - PubMed
    1. Chronic Kidney Disease (CKD) Management in General Practice. 2nd edition. Melbourne: Kidney Health Australia; 2012.
    1. Solberg LI. Guideline implementation: why don’t we do it? Am Fam Physician. 2002;65:176–82. 181–2. - PubMed

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