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. 2015 Sep;14(3):578-85.
doi: 10.1007/s12663-014-0697-6. Epub 2014 Oct 22.

Efficacy of Simvastatin in Bone Regeneration After Surgical Removal of Mandibular Third Molars: A Clinical Pilot Study

Anil Singh Chauhan  1 , Anisha Maria  1 , Anil Managutti  1
Affiliations

Efficacy of Simvastatin in Bone Regeneration After Surgical Removal of Mandibular Third Molars: A Clinical Pilot Study

Anil Singh Chauhan et al. J Maxillofac Oral Surg. 2015 Sep.

Abstract

Introduction: Simvastatin, a common cholesterol-lowering drug that inhibits hepatic hydroxymethylglutaryl coenzyme A reductase, the rate-limiting enzyme in the mevalonate pathway, increases expression of the BMP-2 gene and thus promotes bone regeneration.

Materials and methods: A study was conducted in mandibular third molar sockets to study the efficacy of the drug by implanting it into sockets (experimental group) and observations were made over 3 months to compare the healing with the (control group).

Conclusion: The results showed faster regeneration of the bone in the simvastatin site using the gray level histogram values.

Keywords: Bone regeneration; Simvastatin; Third molar sockets.

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Figures

Fig. 1
Fig. 1
Mean values for percentage of facial swelling between control and study group on different days
Fig. 2
Fig. 2
Mean values on different days for VAS for pain between control and study groups
Fig. 3
Fig. 3
Mean values on different days for gray level histogram values between control and study groups
Fig. 4
Fig. 4
Intra oral periapical radiographs: Case 1
Fig. 5
Fig. 5
Intra oral periapical radiographs: Case 2
See this image and copyright information in PMC

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