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. 2015 Sep;14(3):808-15.
doi: 10.1007/s12663-014-0738-1. Epub 2015 Jan 23.

Mandibular Third Molar Extraction Wound Healing With and Without Platelet Rich Plasma: A Comparative Prospective Study

Shubha Ranjan Dutta  1 , Purnima Singh  2 , Deepak Passi  3 , Pradeep Patter  4
Affiliations

Mandibular Third Molar Extraction Wound Healing With and Without Platelet Rich Plasma: A Comparative Prospective Study

Shubha Ranjan Dutta et al. J Maxillofac Oral Surg. 2015 Sep.

Abstract

Aims: To evaluate the efficacy of autologous platelet rich plasma (PRP) in regeneration of bone and to assess clinical compatibility of the material in mandibular third molar extraction socket.

Objective of the study: To compare the healing of mandibular third molar extraction wounds with and without PRP.

Materials and methods: Group A consists of the 30 patients where PRP will be placed in the extraction socket before closure of the socket. Group B consists of 30 patients who will be the control group where the extraction sockets will be closed without any intra socket medicaments. The patients would be allocated to the groups randomly.

Results: Soft tissue healing was better in study site compared to control site. The result of the study shows rapid bone regeneration in the extraction socket treated with PRP when compared with the socket without PRP. Evaluation for bone blending and trabecular bone formation started earlier in PRP site compared to control, non PRP site. Also there was less postoperative discomfort on the PRP treated side.

Conclusion: Autologous PRP is biocompatible and has significant improved soft tissue healing, bone regeneration and increase in bone density in extraction sockets.

Keywords: Bone density; Bone trabeculae; Mandibular third molar extraction socket; Platelet rich plasma; Soft tissue healing.

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Figures

Fig. 1
Fig. 1
Case 1: A Radiograph (IOPA) at 3rd week post operatively, B radiograph (IOPA) at 2nd month post operatively, C radiograph (IOPA) at 4th month post operatively
Fig. 2
Fig. 2
Case 2: A Radiograph (IOPA) at 3rd week post operatively, B radiograph (IOPA) at 2nd month post operatively, C radiograph (IOPA) at 4th month post operatively
Fig. 3
Fig. 3
Case 3: A Radiograph (IOPA) at 3rd week post operatively, B radiograph (IOPA) at 2nd month post operatively, C radiograph (IOPA) at 4th month post operatively
Fig. 4
Fig. 4
Drawing of blood
Fig. 5
Fig. 5
Drawn blood in test tube
Fig. 6
Fig. 6
Cellular layers separation after 1st spin
Fig. 7
Fig. 7
Cellular layers separation after 2nd spin
Fig. 8
Fig. 8
PPP layers separation after 2nd spin
Fig. 9
Fig. 9
PRP before activation
Fig. 10
Fig. 10
PRP activated with CaCl2
Fig. 11
Fig. 11
PRP gel
Fig. 12
Fig. 12
PRP gel placement in extraction socket
See this image and copyright information in PMC

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